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Evidence from clinical trials suggests that sulfasalazine and 5‐aminosalicylic acid (5‐ASA) formulations may be beneficial in patients with mild to moderately active Crohn’s disease, with some limitations. Although overall not as effective as glucocorticosteroids, sulfasalazine at doses of approximately 4–6 g/day has demonstrated superior efficacy to placebo in patients with mildly to moderately active disease. Several studies have failed to demonstrate a significant maintenance benefit with low‐dose sulfasalazine (1. Three controlled trials have shown that 5‐ASA at doses equal to or greater than 3, reviews on steroid sites. Agents such as metronidazole and ciprofloxacin are further alternative treatments in mild‐to‐moderate Crohn’s disease, but their efficacy does not seem superior to that of 5‐ASA.
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